Rihanna, Britney Spears, Katy Perry and Lady Gaga have all recognised her influence on their careers, with Beyonce hailing her a "masterpiece genius".

She's had more top 10 hits than Elvis, sung a Bond song, met Queen Elizabeth and performed at Super Bowl half time. There's even part of an academic discipline devoted to her - Madonna studies.

But now, following news of a stint in intensive care following a "serious bacterial infection", fans have been left scrabbling for positive news around the pop icon's health, not to mention the ticket-holders for her now-on-pause tour which had been due to kick off next month.

While the star is understood to be home and recovering, the media frenzy around her illness is just a small sign of the impact Madonna has had on the world, transcending the music industry to become one of the most recognisable faces of the 20th and 21st centuries - a post-modern icon playing the game by her own rules.

The best-selling female recording artist of all time, her sparkling four-decade career has earned her multiple awards and a place in the Rock & Roll Hall of Fame.

A master of reinvention, those of a certain age who have followed her over the years have been treated to numerous musical styles, as well as a succession of colourful personas.

Hits have ranged from her early pop tunes Into The Groove and True Blue, to the electronic dance beats in Ray Of Light, a country vibe in Don't Tell Me and classic musical theatre in Don't Cry For Me Argentina.

As for her physical makeovers, they have spanned the fingerless gloves and lacey look of her first number one, Like A Virgin, aged just 26, to the much-imitated Jean Paul Gaultier cone bra and scraped back hair of her Blonde Ambition world tour 6 years later.

Then there was the earth goddess hippie look for her Ray Of Light album, her first as a mother, and then the Farrah Fawcett flip hair and leotard look to usher in her 50s.

With each different phase as distinctive as the next - and each one signalling a mini-comeback of sorts - her skill at keeping herself in the headlines means she's rarely been out of the public conscience over the last 44 years.

Always aware of the selling-power of controversy, many moments in her career have dominated the cultural conversation over the decades.

In 1989 her Like A Prayer video scandalised many featuring burning crosses, bleeding stigmata and a sexually active black saint. The Vatican condemned it and Pepsi cancelled a sponsorship deal. The resulting outcry helped the single become a massive hit and her seventh number one on the Hot 100.

In 2003 after opening the MTV VMAs with a performance of Like A Virgin, an on-stage snog with Britney Spears went viral - two years before YouTube came into existence.

And when during a performance in 2015 a wardrobe malfunction saw her pulled backwards down a flight of stairs live on stage, she picked herself up and carried on. She later denied the fall - which left her with whiplash - was a publicity stunt.

And of course, she's got another string to her bow - not just a singer, but also an actress. While many have maligned her acting ability, she has starred in over 20 feature films - including the Oscar-winning 1996 drama Evita - as well as numerous TV shows and commercials.

She's starred opposite industry heavyweights including Rosanna Arquette (Desperately Seeking Susan); Antonio Banderas (Evita) and Warren Beatty (Dick Tracy). And she's also performed on Broadway and the West End.

Plus, she has literature - her 1992 coffee table book Sex, featuring softcore pornography and sadomasochism - topped the New York Times best-seller list for three weeks, selling over 150,000 copies on its first day, becoming the fastest-selling coffee table book of all time.

Considered a bold post-feminist work - and featuring a naked Madonna to boot - it remains one of the most in-demand out-of-print publications of all time.

When it comes to managing her own destiny, Madonna has led the charge from the get-go, writing and producing the majority of her own music from early on in her career, succeeding in moulding and steering her career her way.

A businesswoman as well as an artist, Forbes has named her the top earning female musician 11 times, and estimates her to be worth $580m (£457m) as of 2023.

In 2013 she launched her own skincare range - MDNA Skin.

Unsurprisingly, as a woman at the top of her game and in financial control of her art, her business acumen has led to the Grammy, Brit and Ivor Novello-winning singer being labelled a "control freak".

However, Madonna insists she values collaboration, saying in a 2012 interview: "I can't work on my own… I need to hear what people think all the time."

Battling her way in the industry years before the #MeToo movement, she reportedly rejected the advances of Harvey Weinstein (whose then company Miramax produced her 1991 documentary Truth Or Dare) telling him: "Get away from me, you smell like a f****** ashtray."

Her more recent criticism of ageism and sexism in both the music industry and society, has received widespread media coverage.

So where did it all begin? The eldest girl of a Catholic family of six children, she was born Madonna Louise Ciccone in Michigan in August 1958.

She was named after her mother, whose death from breast cancer when she was aged just five left her bereft. This early loss resulted in Madonna rejecting the idea of having children for many years, saying she "associated motherhood with sacrifice, suffering and ultimately death".

Dropping out of college, and moving to New York in 1978 to pursue a career in entertainment, the then-19-year-old Madonna was raped at knifepoint during her early days in the city.

She has since said she never reported it to police, fearing the humiliation.

Refusing to let the attack phase her, she found a series of jobs including at Dunkin' Donuts and as a coat check girl, before segueing from a backing singer and dancer to a solo performer.

Multiple number one hits followed, across 14 studio albums. And as well as singing, she also plays the piano, guitar, ukulele and drums.

An early adopter of the hands-free headset microphone, the piece of kit has since been informally named in her honour, dubbed the "Madonna mic".

A woman who clearly knows the power of fame, she's used it for good on many occasions.

In 1998 she set up the Ray Of Light Foundation - named after her seventh studio album - promoting peace, equal rights and education for all.

In 2006 she founded the non-profit organisation Raising Malawi, supporting orphans and vulnerable children, many of whom have been directly affected by HIV and AIDS.

And in 2014 she donated money to her hometown Detroit after the city declared itself bankrupt, and in 2020 - as COVID spread around the world - she donated $1m (£788,000) to the Bill & Melinda Gates Foundation to help find a vaccine.

As for her personal life, she's been married twice. First, her notoriously fractious marriage to actor Sean Penn which came to a close in 1989.

She then became an honorary Brit - buying a Wiltshire estate and a London pub and even adopting the accent - after wedding English film director Guy Richie. The couple split in 2008 after eight years of marriage.

She's had many other well-documented relationships with stars - albeit some of them brief - including with Michael Jackson, Tupac, Vanilla Ice and Dennis Rodman.

Alongside her performance career, she is also mother to six children - Lourdes, 26, Rocco, 22 - both her birth-children - and David 17, Mercy, 16, and twins Estere and Stella, 10, who were all adopted from Malawi.

Raised a Catholic, in the early 2000s her devotion to Kabbalah - a form of Eastern mysticism - led her to change her name to Esther, which means "star".

One constant in her career has been her ferocious work ethic. An exercise lover, she has at times worked out for five-hours per day as well as following a strict macrobiotic diet. It's a dedication which has allowed her to maintain a peak level of fitness and tour into her 60s.

So far, she's completed 11 gruelling concert tours - many of them sold out - and two of those broke records.

Her Sticky & Sweet tour, which ran from August 2008 to September 2009, and her 60-date Confessions tour in 2006 both topped the most money grossed on tour by a female entertainer ($194m and $411m respectively).

However, her last few tours have been beset by illness, leaving her unable to satisfy her own brutal work ethic. Multiple dates of her 2019-2020 Madame X tour were called off due to "overwhelming pain", with the star pictured walking with a cane and wearing knee braces.

Now of course, The Celebration tour is on hold following a "serious bacterial infection".

Madonna has previously called cancelling gigs a "punishment", and at the time of her Madame X cancellations told fans that despite considering herself to be "a warrior I never quit, I never give in", she had been forced to stop performing "so that I don't inflict further and irreversible damage to my body".

Despite the setbacks, her tour record as highest-grossing female performer of all time was only broken last year, when she was overtaken by Taylor Swift's The Eras tour.

Perhaps the last word should go to the curatorial director of the Rock and Roll Hall of Fame, Howard Kramer, who said: "Madonna and the career she carved out for herself made possible virtually every other female pop singer to follow... She certainly raised the standards of all of them... She re-defined what the parameters were for female performers."

A re-inventor, a re-definer and a role-model - Madonna may be briefly out, but as her history proves - she's unlikely to stay down for long.