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The bank, which was saved from possible collapse by a $30bn cash injection agreed by major lenders, saw its stock drop by 29% on Tuesday.
It followed the release of its first quarter earnings report that revealed the extent of the challenge it faced to recover the business.
First Republic said the deposit outflow, which amounted to more than half its pre-crisis total, had cooled since the rescue cash was announced but it was yet to recover any meaningful deposits.
Financial market analysts said the amount, which was higher than the market had expected, had revived fears that First Republic could become the third US bank to fail after the collapse of Silicon Valley Bank and Signature Bank.
The crisis of confidence also saw Switzerland's Credit Suisse, which endured a £55bn deposit outflow, forced to merge with rival UBS.
The saga was largely born out of concerns that rising interest rates imposed by central banks to tackle inflation had damaged their balance sheets.
San Francisco-based First Republic said it would move to shrink its balance sheet and slash costs.
Executive pay cuts, it said, would be followed by thousands of job losses to be completed by the end of June.
The bank said it expected to axe between 20%-25% of its workforce, which was reported at 7,200 at the end of last year.
Its results statement did little to support shares of other US regional lenders, with some seeing shares down by more than 5%.
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Analysts said the sector, but especially First Republic, had to assure customers that their deposits remained
safe and investors that they had the liquidity to operate effectively.
Susannah Streeter, head of money and markets at Hargreaves Lansdown, said: "It seems the lifeline thrown to First Republic by large lenders hasn't stopped confidence sinking.
"With almost a quarter of the workforce being axed and a quick-fire asset sale getting underway, investors are sensing panic and fleeing the stock and worries are rising about another banking collapse."