The four-time grand slam winner, who withdrew from last year's tournament citing struggles with her mental health, was beaten in straight sets 7-5 6-4 by 27th seed Anisimova.

The 20-year-old had also beaten Osaka in the third round of this year's Australian Open and is a former French Open semi-finalist in 2019.

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Osaka double-faulted twice on break point, once in each set. After the second, which gave Anisimova a 4-3 lead, Osaka took a 40-0 lead in the next game but the American crucially held serve.

Former world No 1 Osaka played with tape on her left Achilles. She was stretching it and kicking it with her right foot when she was broken in the seventh game of the second set.

Shortly before last year's tournament, Osaka announced that she would not conduct her mandatory media assignments. And after winning her first match in straight sets and failing to hold a press conference, she was fined $15,000 and threatened with rising levels of fines and expulsion. The following day, she announced her withdrawal from the tournament.

Britain's Dart suffers painful first-round exit

Britain's Harriet Dart narrowly avoided a dreaded double-bagel for the second time at a grand slam as she lost 6-0 6-2 to Italy's Martina Trevisan in the first round of the French Open.

The 25-year-old from London failed to win a game in a first-round defeat by Maria Sharapova at the Australian Open in 2019.

Dart must have feared a repeat at 6-0 3-0 down, but she managed to get a couple of games on the board before her early exit from the tournament was finally confirmed.

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